The Interdisciplinary Science & Research (ISR) Program, a partnership between the Vanderbilt Collaborative STEM Education and Outreach and Metropolitan Nashville Public Schools, aims to enhance high school students' understanding of STEM concepts and research principles while empowering teachers through scientific research. Available at Stratford STEM Magnet High School, Hillsboro High School, and John Overton High School, the ISR program is co-taught by a scientist-teacher team, focusing on individualized instruction to meet student needs. In this comprehensive four-year program, students transition from understanding the basics of scientific disciplines in the first year to performing independent research in their junior and senior years. It is designed for students who are passionate about science and math and are willing to commit the efforts required for a rigorous curriculum. The program expects active, collaborative learners who will engage in the process of science, formulating questions, developing and testing hypotheses, and presenting results. Attendance is crucial due to the difficulty in recreating laboratory activities outside of class. The course sequence ranges from 'Interdisciplinary Science I' in the 9th grade, where students develop an understanding of the fundamental concepts essential to scientific inquiry, to 'Interdisciplinary Science IV' in the 12th grade where students conduct an undergraduate-level research project. In the third year, students take a college-level introduction to the field of environmental studies, investigating environmental problems involving complex interconnections between people, ecosystems, and the biosphere. The ISR program is taught by qualified postdoctoral scholars interested in K-12 STEM outreach and education, and STEM curriculum development and implementation, ensuring quality instruction for the students. Upon completion, students will have experienced an interdisciplinary, research-centered learning journey, preparing them to solve 21st-century problems.